p-Phenylenediamine synthesis
- Product Name:p-Phenylenediamine
- CAS Number:106-50-3
- Molecular formula:C6H8N2
- Molecular Weight:108.14
1516-60-5
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106-50-3
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$17.00/25g
Yield:106-50-3 100%
Reaction Conditions:
Stage #1: 4-nitrophenyl azidewith hydrazine hydrate at 135; for 3 h;
Stage #2: with potassium hydroxide at 135; for 24 h;
Steps:
Benzene 1,4-diamine (4)
General procedure: The corresponding substrate (1 mmol) was dissolved in 2 mL of distilled hydrazine hydrate. The mixture was stirred for 3 h in a sealed pressure tube placed in an oil bath at 135 °C. The reaction was then allowed to reach room temperature and KOH (5 mmol) was added. The mixture was allowed to react overnight at 135 °C. It was then extracted with a mixture of DCM and isopropanol 80:20 and washed with water (3x30 mL) and the organic solvent was evaporated to give a residue that was purified by silica gel column chromatography, eluting with hexane:ethylacetate (1:1) to yield the desired products.
References:
Diez-Cecilia, Elena;Kelly, Brendan;Rozas, Isabel [Tetrahedron Letters,2011,vol. 52,# 50,p. 6702 - 6704] Location in patent:supporting information; experimental part
106-40-1
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106-50-3
620 suppliers
$17.00/25g
540-37-4
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$6.00/5g
106-50-3
620 suppliers
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100-01-6
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$11.19/25G
106-50-3
620 suppliers
$17.00/25g
98-95-3
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$14.00/25g
106-50-3
620 suppliers
$17.00/25g