5-Ethoxy-4-methyloxazole synthesis
- Product Name:5-Ethoxy-4-methyloxazole
- CAS Number:5006-20-2
- Molecular formula:C6H9NO2
- Molecular Weight:127.14
23429-04-1
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5006-20-2
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Yield:5006-20-2 93.7 %Chromat.
Reaction Conditions:
with toluene-4-sulfonic acid;acetic acid in toluene at 90; for 3 h;Solvent;Temperature;Reagent/catalyst;
Steps:
7-8; 10 Example 7
In a reaction flask, add 19.9g4-methyl-5-ethoxyoxazolecarboxylic acid ethyl ester (0.1 mol), 8.58 mL of acetic acid (0.15 mol) and 0.86 g of p-toluenesulfonic acid (0.005 mol),Then, 20 mL of toluene was added, and the mixture was stirred at 90 ° C for 3 hours.After the system has no bubbles, the reaction is over.The internal standard yield of 4-methyl-5-ethoxyoxazole detected by gas chromatography was 93.5% (n-dodecane was the internal standard).At the same time, 4.1% of N-formylalanine ethyl ester was generated (area normalization method).
References:
Shandong Xinhe Cheng Jinghua Technology Co., Ltd.;Zhejiang Xinhecheng Co., Ltd.;Chen Weiyong;Zhao Lei;Huang Jian;Wang Haitao;Sheng Meilan;Wu Yuanyuan;Wu Xudong;Liang Hao;Su Weiwei CN110713468, 2020, A Location in patent:Paragraph 0046-0049; 0052-0053
4289-99-0
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23429-05-2
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17344-99-9
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5006-20-2
136 suppliers
$21.00/250mg