Yield:-

Reaction Conditions:

with triethylamine in N-methyl-acetamide;water;

Steps:

9 EXAMPLE 9

EXAMPLE 9 To a solution of 20 g. of 2-p-chlorophenyl-5-ethoxy-4-oxazoleacetic acid in 100 ml. of dimethylformamide are added 60 ml. of triethylamine and 40 ml. of ethyl bromide, and the mixture is stirred overnight at room temperature. The course of the reaction is followed by thin-layer chromatography. When the starting compounds disappear, 1 liter of water is added to the reaction mixture, and the mixture is extracted with ethyl acetate. The organic layer is washed with water, with dilute hydrochloric acid and further with water, and then dried and concentrated. The residue is recrystallized from hexane to give 19.0 g. of ethyl 2-p-chlorophenyl-5-ethoxy-4-oxazoleacetate melting at 84° - 85° C.

References:

US4012412,1977,A