5-Fluoro-2-nitropyridine synthesis
- Product Name:5-Fluoro-2-nitropyridine
- CAS Number:779345-37-8
- Molecular formula:C5H3FN2O2
- Molecular Weight:142.09
5-Fluoro-2-nitropyridine can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes. It can be synthesized by nitration of 5-fluoro-2-amino-pyridine and concentrated sulfuric acid under low temperature conditions.
21717-96-4
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$10.00/1g
779345-37-8
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$36.00/250mg
Yield:779345-37-8 77%
Reaction Conditions:
with sulfuric acid;dihydrogen peroxide
Steps:
429 429A-Preparation of 5-Fluoro-2-nitro-pyridine
429A-Preparation of 5-Fluoro-2-nitro-pyridine To concentrated H2SO4 at 0° C. was added 4 ml of 3% H2O2. To this solution at 0° C. was added 5-fluoro-2-amino-pyridine (250 mg, 2.23 mmol). The mixture was warmed to room temperature and stirred for 20 hr, then poured onto ice. The aqueous solution was extracted with EtOAc (3*30 ml). The combined organic layers were washed with water, brine and dried with Na2SO4. Removal of the solvent gave a light brown oil (245 mg, 77%). The product was used for next step without further purification.
References:
Salvati, Mark E.;Illig, Carl R.;Wilson, Kenneth Jerome;Chen, Jinsheng;Meegalla, Sanath K.;Wall, Mark James US2004/209886, 2004, A1