5-METHYLHEXANOIC ACID synthesis
- Product Name:5-METHYLHEXANOIC ACID
- CAS Number:628-46-6
- Molecular formula:C7H14O2
- Molecular Weight:130.18
Yield:628-46-6 57%
Reaction Conditions:
with [2,2]bipyridinyl;bis(1,5-cyclooctadiene)nickel (0);zinc in N,N-dimethyl acetamide at 80; for 12 h;
Steps:
21 Example 1
General procedure: In the glove box, bis-(1,5-cyclooctadiene)nickel (8.3mg, 0.03mmol) and 2,2'-bipyridine, which is the chemical structural formula structural formula L1, (7.0mg, 0.045mmol) into the microwave tube,Add 0.225mL N,N-dimethylacetamide for coordination for one hour, add zinc powder (39.2mg, 0.6mmol, 2.0 equivalent) into the microwave tube,Then add succinic anhydride (0.45mmol, 1.5eq) and 1-bromooctane (0.3mmol, 1.0eq), cover it and take it out from the glove box, reflux at 80 for 12 hours,Cool to room temperature, uncap and add three drops of water to quench the reaction, remove the solvent under reduced pressure,The crude product is separated by column chromatography (petroleum ether: ethyl acetate = 5:1) to obtain 11 alkanic acid (47.0 mg, 84% yield).
References:
Nanjing Tech University;Mao Jianyou;Lin Tingzhi;Qian Pengcheng;Gu Yuanyun CN111533649, 2020, A Location in patent:Paragraph 0028-0032; 0055
![1,2-diaza-bicyclo[2.2.2]octane](/CAS/GIF/329-94-2.gif)
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