Ursodeoxycholic acid synthesis
- Product Name:Ursodeoxycholic acid
- CAS Number:128-13-2
- Molecular formula:C24H40O4
- Molecular Weight:392.57
10538-55-3
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128-13-2
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Yield:128-13-2 99%
Reaction Conditions:
with methanol;sodium methylate at 25;
Steps:
2 Example 2
The compound of Formula 2 (38.8 g, 95.6 mmol) was dissolved in a 2 mol/L sodium methoxide/methanol solution (200 mL), and the reaction was stopped after stirring at room temperature for 3 hours. 200 mL of ethyl acetate and 200 mL of water were added for extraction. The organic phase was washed three times with 100 mL of saturated brine and dried. Concentration of ethyl acetate was performed to remove the solvent, and the compound of Formula 1 was obtained as a white foamy solid (37.1 g, 99%). %). Recrystallize with 80% ethanol in water to obtain a white crystalline powder.
References:
CN107793464,2018,A Location in patent:Paragraph 0006; 0026; 0027
4651-67-6
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128-13-2
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911-40-0
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128-13-2
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474-25-9
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128-13-2
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10452-65-0
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128-13-2
729 suppliers
$30.00/20mg