5-Nitropyridine-2-carboxylic acid synthesis
- Product Name:5-Nitropyridine-2-carboxylic acid
- CAS Number:30651-24-2
- Molecular formula:C6H4N2O4
- Molecular Weight:168.11
4487-59-6
30651-24-2
General procedure for the synthesis of 5-nitro-2-pyridinecarboxylic acid from 2-bromo-5-nitropyridine: this method is based on the procedure reported by Oehlke, J.; Schroetter, E.; Dove, S.; Schick, H.; Niedrich, H. in Pharmazie 1983,38,591-596, with slight modifications. When N,N-dimethylformamide (DMF) was used instead of dimethylsulfoxide (DMSO) as solvent for the reaction with 2-bromo-5-nitropyridine and copper(I) cyanide, a subsequent hydrolysis step afforded the target product 5-nitro-2-pyridinecarboxylic acid in 70% yield. This product is usually used directly in subsequent reactions without further purification.
60891-70-5
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30651-24-2
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Yield:30651-24-2 74%
Reaction Conditions:
with nitric acid for 15 h;Reflux;
Steps:
24 Preparation of 5-nitropyridine-2-carboxylic acid (Compound 24B)
Compound 24A (2.4 g, 8.5 mmol) was dissolved in 65% nitric acid (60 mL).The reaction solution was refluxed for 15 hours. Concentrated dry, washed with chloroform, filtered to give compound 24B (1 g, 74% yield).
References:
Jiangsu Xiansheng Pharmaceutical Co., Ltd.;Chen Huanming;Liang Bo;Cao Wenjie;Zhang Guiping;Zhao Zhongqiang;Jiang Zhaojian;Zuo Gaolei;Xu Wanmei;Gong Hongju;Zhang Peng;Wang Jianghuai;Li Qingsong;Gao Chunhua CN104045552, 2019, B Location in patent:Paragraph 0299; 0300; 0303; 0304
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30651-24-2
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544-92-3
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30651-24-2
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68719-87-9
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30651-24-2
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21203-68-9
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30651-24-2
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