一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 2-Picolinic acid
98-98-6

2-Picolinic acid synthesis

11synthesis methods
2-Picolinic acid synthesis: In a 500ml three-necked flask, add 100g of 2-cyanopyridine and 200g of deionized water, then start stirring, heat up to 50°C, add 128.2g of 30% sodium hydroxide to the flask, after adding, add Continue to heat up, react under reflux for 4 hours, then distill water, after 50 g of distilled water, cool the reaction solution to 20°C, add 30% hydrochloric acid, adjust the pH value of the reaction solution to 2.5, then turn on the steam to heat up the water and steam to the kettle When the temperature reaches 120°C, the reaction solution is evaporated to dryness, and the distilled water is completed. Then, 300 g of anhydrous alcohol is added dropwise to the flask to maintain the temperature of the reaction solution at 55°C. After cooling and crystallization, a solid was precipitated, filtered and dried to obtain 106.0 g of 2-picolinic acid with a yield of 89.6%.
-

Yield:98-98-6 97%

Reaction Conditions:

with tert-butyldimethylsilyl chloride in methanol;water at 20; for 0.5 h;Green chemistry;

Steps:

Synthesis of carboxylic acids pyridine-2-carboxylic acid (7), thiophene-2-carboxylic acid (8) or furan-2-carboxylic acid (9)

An appropriate alcohol [2-pyridinemethanol (3) (1.0 g, 9.20 mmol, 1 eq), 2-thiophenemethanol (4) (1.0 g, 8.78 mmol, 1 eq) or 2-furanmethanol (5) (1.0 g,10.20 mmol] was added to reaction mixture that contained Ag/ZnO/graphene nanocomposite (10 mg, 1 wt%), and TBSCl (1.38 g, 9.20 mmol, 1 eq), (1.32 g, 8.78 mmol, 1 eq), (1.53 g, 10.20 mmol, 1 eq) or (1.38 g, 9.26 mmol, 1 eq) dissolved in MeOH:H2O (1:1, 10 mL). The mixture was stirred for 30, 60 or 60 min, respectively, at room temperature and monitored by TLC using eluent system (EtOAc:Hexane, 3:7). The mixture was filtrated and then water (5 mL) was added, and the mixture was extracted with (CHCl3: MeOH, 1:1) (5 mL * 2). The collected methanol/water layer was evaporated using rotary evaporator to afford the residue that was purified by column chromatography using silica gel (Hexane:EtOAc, 7:3, 6:4 and then 1:1) to afford the corresponding carboxylic acids; pyridine-2-carboxylic acid (7); thiophene-2-carboxylic acid (8) or furan-2-carboxylicacid (9) respectively.

References:

Attia, Yasser A.;Vázquez, Carlos Vázquez;Mohamed, Yasser M. A. [Research on Chemical Intermediates,2017,vol. 43,# 1,p. 203 - 218]

2-Picolinic acid Related Search:

遂川县| 海宁市| 临清市| 满洲里市| 扎兰屯市| 肇州县| 梓潼县| 大同县| 高唐县| 镶黄旗| 罗平县| 南澳县| 灌南县| 阿克陶县| 临沂市| 江西省| 兴业县| 休宁县| 格尔木市| 抚宁县| 承德市| 铜鼓县| 石林| 新化县| 英德市| 灵山县| 溆浦县| 巴彦县| 铜山县| 渝中区| 南雄市| 抚州市| 永兴县| 高清| 阿拉善盟| 都江堰市| 建宁县| 通化县| 五常市| 搜索| 股票|