tert-butyl 4-(3-nitrophenoxy)piperidine-1-carboxylate synthesis
- Product Name:tert-butyl 4-(3-nitrophenoxy)piperidine-1-carboxylate
- CAS Number:586412-88-6
- Molecular formula:C16H22N2O5
- Molecular Weight:322.36
591-27-5
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Yield:586412-88-6 85%
Reaction Conditions:
with di-isopropyl azodicarboxylate;triphenylphosphine in tetrahydrofuran at 70; for 4 h;
Steps:
2 Step 2-tert-butyl 4-(3-nitrophenoxy)piperidine-1-carboxylate (1c)
Weigh 4-hydroxypiperidine-1-carboxylate 1b (8g, 40mmol), placed in 250mL round bottom flask, the reaction flask was added tetrahydrofuran (100 mL), stir. To the reaction flask were sequentially added m-aminophenol (4.36g, 40 mmol), triphenylphosphine (15.7g, 60mmol) and isopropyl azodicarboxylate (12g, 60mmol), stirring the reaction was raised to 70 4 h, concentrated under reduced pressure, the residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate (v / v)= 4: 1) to give yellow oily 4 - (3-nitrophenoxy) piperidine-1-carboxylic acid tert-butyl 1c (10.9g, yield 85%).
References:
CN105384695,2016,A Location in patent:Paragraph 0162; 0167; 0168; 0169; 0170; 0171
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