1-Fluoro-3-nitrobenzene synthesis
- Product Name:1-Fluoro-3-nitrobenzene
- CAS Number:402-67-5
- Molecular formula:C6H4FNO2
- Molecular Weight:141.1
394-01-4
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$8.00/5g
402-67-5
271 suppliers
$6.00/5g
Yield:402-67-5 42%
Reaction Conditions:
with 2.9-dimethyl-1,10-phenanthroline;oxygen;copper (I) acetate;silver sulfate;sodium chloride in dimethyl sulfoxide at 160; for 24 h;Schlenk technique;
Steps:
8 Example 8. Synthesis of 2-nitro-4-fluorobenzene.
Silak reaction tube equipped with a magnetic stirrer was charged with 6.2 mg of silver sulfate,36.3 mg of copper acetate, 12.5 mg of 2,9-dimethyl-1,10-o-phenanthroline,37 mg of 2-nitro-4-fluorobenzoic acid, and 17.5 mg of sodium chloride4 mL of dimethyl sulfoxide. Heat 160 ° C in the presence of oxygenReaction for 24 hours. After the reaction was completed, distilled water was added to quench the reaction,Extraction with ethyl acetate 3 times, each time 10mL,The combined organic phases were concentrated to give 14.7 mg of 2-nitro-4-fluorobenzene,The yield is 42%.
References:
Nanchang University;Fu Zhengjiang;Cai Hu;Li Zhaojie;Jiang Ligao CN107325002, 2017, A Location in patent:Paragraph 0067
369-35-7
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402-67-5
271 suppliers
$6.00/5g
99-09-2
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$14.00/1g
402-67-5
271 suppliers
$6.00/5g
585-79-5
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$15.00/1g
402-67-5
271 suppliers
$6.00/5g
99-65-0
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$31.39/442244
402-67-5
271 suppliers
$6.00/5g