6-Acetoxy-4-chloro-7-methoxyquinazoline synthesis
- Product Name:6-Acetoxy-4-chloro-7-methoxyquinazoline
- CAS Number:230955-75-6
- Molecular formula:C11H9ClN2O3
- Molecular Weight:252.65
199327-61-2
270 suppliers
$6.00/1g
230955-75-6
150 suppliers
$11.00/250mg
Yield:230955-75-6 93.7%
Reaction Conditions:
with sulfuryl dichloride in acetonitrile at 55;Temperature;Concentration;
Steps:
1
1) exchange resin 12.8g in D301 macroporous weakly basic styrene anion, 6- (2-morpholino-ethoxy) -7-methoxy-3,4-dihydro-quinazolin-4 ketone (31.9g, 100mol), sulfuryl chloride (16.2g, 120mmol) in 100ml acetonitrile were contact reaction, the contact reaction temperature was 55 , after the reaction was quenched with ice-water, extracted with methylene chloride, concentrated under reduced pressure to give 6-acetoxy-4-chloro-7-methoxy-quinazoline of 31.7g, a yield of 93.7%, a purity of 99.05%.
References:
Chen, Hong;He, Baohong CN105541737, 2016, A Location in patent:Paragraph 0026; 0034
179688-53-0
271 suppliers
$6.00/1g
230955-75-6
150 suppliers
$11.00/250mg
179688-53-0
271 suppliers
$6.00/1g
230955-75-6
150 suppliers
$11.00/250mg
179688-53-0
271 suppliers
$6.00/1g
230955-75-6
150 suppliers
$11.00/250mg
7719-09-7
415 suppliers
$15.00/10g
179688-53-0
271 suppliers
$6.00/1g
230955-75-6
150 suppliers
$11.00/250mg