6-Bromo-N,N-dimethylnicotinamide synthesis
- Product Name:6-Bromo-N,N-dimethylnicotinamide
- CAS Number:869640-49-3
- Molecular formula:C8H9BrN2O
- Molecular Weight:229.07
6311-35-9
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506-59-2
553 suppliers
$5.00/5G
869640-49-3
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$100.00/100mg
Yield:869640-49-3 90%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine;N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate in dichloromethane at 20;Inert atmosphere;
Steps:
8 6-bromo-N,N-dimethylnicotinamide
6-bromo-N,N-dimethylnicotinamide (0260) To a solution of 6-bromopyridine-3-carboxylic acid (200 mg, 0.99 mmol) in dicholormethane (5 mL) were added dimethylamine hydrochloride (97 mg, 1.19 mmol), HATU (564 mg, 1.48 mmol) and DIEA (639 mg, 4.94 mmol) at room temperature. The resulting mixture was stirred overnight at room temperature and then was quenched by the addition of water (20 mL). The reaction mixture was extracted with ethyl acetate (50 mL×3). The organic phases were combined, washed with brine and dried over sodium sulfate. The solvent was removed under reduced pressure and the residue was purified by flash chromatography eluting with ethyl acetate in hexane (0% to 50% gradient) to yield 6-bromo-N,N-dimethylpyridine-3-carboxamide as colorless oil (203 mg, 90%). MS: m/z=229.0 [M+H]+.
References:
US2016/376283,2016,A1 Location in patent:Paragraph 0259; 0260
6311-35-9
375 suppliers
$15.00/1g
124-40-3
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$18.00/100ml
869640-49-3
24 suppliers
$100.00/100mg
124-40-3
541 suppliers
$18.00/100ml
869640-49-3
24 suppliers
$100.00/100mg
26218-78-0
232 suppliers
$6.00/1g
869640-49-3
24 suppliers
$100.00/100mg