6-Bromopyridine-2-carboxamide 98% synthesis
- Product Name:6-Bromopyridine-2-carboxamide 98%
- CAS Number:25194-52-9
- Molecular formula:C6H5BrN2O
- Molecular Weight:201.02
21190-87-4
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25194-52-9
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Yield: 100%
Reaction Conditions:
with ammonium chloride;benzotriazol-1-ol;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;N-ethyl-N,N-diisopropylamine at 20;
Steps:
1 Step 1: Preparation of 6-bromopicolinamide
General procedure: Step 1: Preparation of 6-bromopicolinamide Using the same reaction conditions as described in step 6 of example 1 , 6-bromopicolinic acid (2g, 9.9 mmol) was coupled with ammonium chloride (787mg, 14.851 mmol) using EDCI.HC1 (2.8g, 14.851 mmol), HOBt (2.0g, 14.851 mmol) and DIPEA (3.8g, 29.750 mmol) in DMF (lOmL) to get the crude product. The resultant crude was purified using 60-120 silica- gel column chromatography and compound was eluted using 50% ethyl acetate in hexane as eluent to afford the title compound (2.0g, 100%). 1HNMR (CDCI3, 300MHz): δ 8.18-8.16 (d, 1H), 7.7.63-7.5656-7.63 (m, 2H), 5.80-5.60 (bs, 2H). +.
References:
AURIGENE DISCOVERY TECHNOLOGIES LIMITED;GUMMADI, Venkateshwar, Rao;SAMAJDAR, Susanta WO2015/104688, 2015, A1 Location in patent:Page/Page column 23-24
122918-25-6
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25194-52-9
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$22.00/250mg
139487-69-7
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25194-52-9
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26218-75-7
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25194-52-9
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$22.00/250mg
21190-87-4
391 suppliers
$10.00/5g
530-62-1
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25194-52-9
92 suppliers
$22.00/250mg