6-CHLORO-2-FLUORO-3-METHYLBENZAMIDE synthesis
- Product Name:6-CHLORO-2-FLUORO-3-METHYLBENZAMIDE
- CAS Number:286474-61-1
- Molecular formula:C8H7ClFNO
- Molecular Weight:187.6
79-37-8
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Yield:-
Reaction Conditions:
Stage #1: oxalyl dichloride;6-chloro-2-fluoro-3-methylbenzoic acid;N,N-dimethyl-formamide in dichloromethane;
Stage #2: with ammonia in water at 0;
Steps:
1.E
To β-chloro^-fluoro-S-methylbenzoic acid (10 g, 53 mmol) is added CH2CI2 {60 mL), DMF (0.5 mL) and oxalyl chloride (9.25 mL, 106 mmol). The reaction mixture is allowed to stir until it reaches homogeneity and is then concentrated in vacuo. The residue is poured onto a 50:50 mixture of ice and 36% ammonium hydroxide to yield 6-chloro-2-fluoro-3- methylbenzamide
References:
WO2008/2853,2008,A2 Location in patent:Page/Page column 23-24