6-FLUORO-4-HYDROXYQUINOLINE synthesis
- Product Name:6-FLUORO-4-HYDROXYQUINOLINE
- CAS Number:21873-50-7
- Molecular formula:C9H6FNO
- Molecular Weight:163.15
![5-[(4-fluoroanilino)methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione](/CAS/20180601/GIF/332129-58-5.gif)
332129-58-5
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21873-50-7
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Yield:21873-50-7 94%
Reaction Conditions:
with dowtherm A for 0.166667 h;Heating / reflux;
Steps:
10.b
Intermediate (10a) (10.9 g, 41 mmol) was slowly added over five minutes to refluxing Dowtherm A (50 ml). After an additional five minutes at reflux, the mixture was allow to cool to room temperature then ether (50 ml) was added. The product was filtered off, thoroughly washed with ether then dried in vacuo to afford the product as a gold coloured solid (16.2 g, 94%). MS (+ve ion electrospray) m/z 164 (MH+).
References:
WO2004/14361,2004,A1 Location in patent:Page/Page column 41
71083-00-6
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21873-50-7
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