6-FLUORO-4-HYDROXY-2-METHYLQUINOLINE synthesis
- Product Name:6-FLUORO-4-HYDROXY-2-METHYLQUINOLINE
- CAS Number:15912-68-2
- Molecular formula:C10H8FNO
- Molecular Weight:177.18
141-97-9
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Yield:-
Reaction Conditions:
with polyphosphoric acid at 80 - 120; for 16.75 h;
Steps:
1.2. Experimental procedure for the synthesis of compounds (8b) and (9b)
Substituted aniline (7b) (4.5g, 40.1mmol) and PPA (240mL) was heated to 80°C, ethyl acetoacetate (6.3g, 47.8mmol) was added drop wise for 45min and heated to 120°C for 16h.Completion of the reaction was monitored by TLC. The RM was poured over crushed ice and neutralized with aqueous ammonia (25%); solid precipitated was filtered, washed with diethyl ether and dried. The pure compounds were isolated by column chromatography using silica gel 230-400, eluting with 20% ethyl acetate in hexane.
References:
Gopinath, Vadiraj S.;Pinjari, Jakir;Dere, Ravindra T.;Verma, Aditya;Vishwakarma, Preeti;Shivahare, Rahul;Moger, Manjunath;Kumar Goud, Palusa Sanath;Ramanathan, Vikram;Bose, Prosenjit;Rao;Gupta, Suman;Puri, Sunil K.;Launay, Delphine;Martin, Denis [European Journal of Medicinal Chemistry,2013,vol. 69,p. 527 - 536] Location in patent:supporting information
371-40-4
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15912-68-2
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$21.00/250mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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15912-68-2
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18529-17-4
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15912-68-2
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$21.00/250mg