6-PHENOXY-3-PYRIDINAMINE synthesis
- Product Name:6-PHENOXY-3-PYRIDINAMINE
- CAS Number:25194-67-6
- Molecular formula:C11H10N2O
- Molecular Weight:186.21
28222-02-8
18 suppliers
$120.00/1g
25194-67-6
64 suppliers
$24.73/250mgs:
Yield:25194-67-6 87%
Reaction Conditions:
with hydrogenchloride;tin(ll) chloride in ethanol;water at 50; for 3 h;
Steps:
25
EXAMPLE 25 Preparation of 1H-indole-3-carboxylic acid(6-phenoxy-pyridine-3-yl)-amide Phenol (1.0 g, 10.6 mmol) was dissolved in DMF (20 ml), and the solution was stirred with NaH (430 mg, 10.51 mmol) and 2-chloro-5-nitro pyridine (1.68 g, 10.6 mmol) at room temperature for 8 hours. Subsequently, the product was filtered, washed, and dried under reduced pressures to yield a solid product (1.7 g, 99%). The solid product (2.0 g, 9.25 mmol) was added to a mixed solution of ethanol (20 ml) and conc. hydrochloric acid (5 ml), SnCl2 (5.26 g, 27.75 mmol) was added to the mixture, and the resulting solution was stirred at 50° C. for 3 hours. And then the product was filtered, washed, and dried to prepare 6-phenoxypyridine-3-amine (1.5 g, 87%).
References:
US2009/258876,2009,A1 Location in patent:Page/Page column 14
4548-45-2
544 suppliers
$6.00/5g
28222-02-8
18 suppliers
$120.00/1g
1643-19-2
1059 suppliers
$12.00/10g
108-95-2
781 suppliers
$14.00/25g
25194-67-6
64 suppliers
$24.73/250mgs:
4548-45-2
544 suppliers
$6.00/5g
25194-67-6
64 suppliers
$24.73/250mgs:
108-95-2
781 suppliers
$14.00/25g
25194-67-6
64 suppliers
$24.73/250mgs:
4487-59-6
448 suppliers
$5.00/1g
25194-67-6
64 suppliers
$24.73/250mgs: