7-Bromo-1-tetralone synthesis
- Product Name:7-Bromo-1-tetralone
- CAS Number:32281-97-3
- Molecular formula:C10H9BrO
- Molecular Weight:225.08
A mixture of 4-(8-methoxynaphthalen-2-yl)-2-methyl-1,2,3,4-tetrahydroisoquinoline maleate (57 g, 223 mmol), potassium hydroxide (43 g, 760 mmol), and hydrazine hydrate (26 m1, 830 mmol) in diethylene glycol (2,865 ml) was stirred for 3 hr at 195 °C. Af
35656-89-4
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32281-97-3
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Yield:32281-97-3 95%
Reaction Conditions:
with phosphorus pentoxide in toluene at 110; for 2 h;Temperature;Time;
Steps:
1 Example 1
The effect of the ratio of the amount of the different condensing agent on the yield of the product.The use of phosphorus pentoxide as a dehydrating agent, the use of toluene as the solvent, the fixed reaction temperature was 110 , the reaction time was 2h,Exploring the effect of the ratio of 4 - (4 - bromophenyl) butanoic acid and phosphorus pentoxide on the product yield, the results are shown in Table 1. ;_ The ratio of the amount of 4- (4 - bromophenyl) butyric acid and phosphorus pentoxide fixed in 1: 3 was determined by using toluene as solvent and the reaction time was 2h. The effect of different reaction temperature on the yield of product was explored. The results are shown in Table 2. ;_ Fixing the ratio of the amount of substance of 4- (4 - bromophenyl) butyric acid: phosphorus pentoxide to 1: 3, using toluene as solvent and the reaction temperature of 110 , the effects of different time on product yield were explored,The results are shown in Table 3.
References:
CN107141202,2017,A Location in patent:Paragraph 0011-0013; 0014-0016; 0017-0019
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