7-Chloro-2-methylquinoline synthesis
- Product Name:7-Chloro-2-methylquinoline
- CAS Number:4965-33-7
- Molecular formula:C10H8ClN
- Molecular Weight:177.63
109-92-2
108-42-9
4965-33-7
To a 50 mL round-bottomed flask equipped with a condenser and a PTFE stirrer was added m-chloroaniline (1 mmol), acetonitrile (5 mL), Catalyst 1 (10 mol%), and vinyl ether (3 mmol). The reaction mixture was heated in air at 80 °C for the reaction time referred to Table 1. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to afford 7-chloro-2-methylquinoline. The structure of the product was confirmed by comparing the spectral data reported in the literature.
123-42-2
604 suppliers
$22.50/100ml
59236-37-2
61 suppliers
$14.00/100mg
4965-33-7
418 suppliers
$9.00/5g
Yield:4965-33-7 90%
Reaction Conditions:
with chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I);sodium t-butanolate in toluene at 70;Inert atmosphere;Schlenk technique;chemoselective reaction;
References:
Zhang, Song-Lin;Deng, Zhu-Qin [Organic and Biomolecular Chemistry,2016,vol. 14,# 38,p. 8966 - 8970] Location in patent:supporting information
123-73-9
232 suppliers
$40.00/5g
121-73-3
78 suppliers
$10.00/1g
108-42-9
474 suppliers
$10.00/5g
4965-33-7
418 suppliers
$9.00/5g
109-92-2
274 suppliers
$19.00/25mL
108-42-9
474 suppliers
$10.00/5g
4965-33-7
418 suppliers
$9.00/5g