4-(5-BROMOPYRIDIN-2-YL)TETRAHYDRO-2H-PYRAN-4-CARBONITRILE synthesis
1synthesis methods
- Product Name:4-(5-BROMOPYRIDIN-2-YL)TETRAHYDRO-2H-PYRAN-4-CARBONITRILE
- CAS Number:831203-30-6
- Molecular formula:C11H11BrN2O
- Molecular Weight:267.12
Yield:831203-30-6 99%
Reaction Conditions:
Stage #1: tetrahydro-4H-pyran-4,4-dicarbonitrilewith methylmagnesium chloride;lithium chloride in tetrahydrofuran;toluene at 20; for 1 h;Sealed tube;Inert atmosphere;
Stage #2: 2-fluoro-5-bromo-pyridine in tetrahydrofuran;diethyl ether;toluene at 50; for 12 h;Sealed tube;Inert atmosphere;
References:
Mills, L. Reginald;Patel, Purvish;Rousseaux, Sophie A. L. [Organic and Biomolecular Chemistry,2022,vol. 20,# 30,p. 5933 - 5937] Location in patent:supporting information