4-(4-BROMO-BENZOYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER synthesis
- Product Name:4-(4-BROMO-BENZOYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS Number:867333-30-0
- Molecular formula:C16H21BrN2O3
- Molecular Weight:369.25
586-75-4
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57260-71-6
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867333-30-0
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Yield:867333-30-0 100%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in dichloromethane at 0 - 20;
Steps:
1.1 Example 1 1 -[4-(4-isoquinolin-6-yl-benzoyl)-piperazin-1 -yl]-propan-1 -one ("A1 ")
1.1 Tert-butyl 1-piperazinecarboxylate (0.5 g; 2.69 mmol) was dissolved in 10 ml of dichloromethane (DCM). N-ethyldiisopropylamine for synthesis (1.37 ml; 8.06 mmol) was added and the mixture cooled down to 0°C. Now 4- bromobenzoyl chloride for synthesis (0.66 g; 2.95 mmol) was dissolved in 10 ml of DCM and added dropwise to the reaction, followed by stirring at RT overnight. Regarding to LC-MS the reaction was complete. The reaction mixture was extracted with 50 ml_ of water. The organic layer was dried over MgS04, filtered off and then reduced to dryness under vacuo to afford 1 ,0 g (100%) 4-(4-bromo-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester 1 as beige solid.
References:
WO2014/146747,2014,A1 Location in patent:Page/Page column 44
586-76-5
522 suppliers
$10.00/1g
57260-71-6
723 suppliers
$5.00/5g
867333-30-0
23 suppliers
$189.53/1g
1122-91-4
713 suppliers
$9.00/10g
57260-71-6
723 suppliers
$5.00/5g
867333-30-0
23 suppliers
$189.53/1g
586-75-4
231 suppliers
$10.00/5g
867333-30-0
23 suppliers
$189.53/1g