9-Hydroxyxanthene synthesis
- Product Name:9-Hydroxyxanthene
- CAS Number:90-46-0
- Molecular formula:C13H10O2
- Molecular Weight:198.22
90-47-1
272 suppliers
$14.00/5g
90-46-0
187 suppliers
$25.00/5G
Yield:90-46-0 94%
Reaction Conditions:
with ethanol;sodium hydroxide;zinc at 20; for 4 h;Reflux;Concentration;
Steps:
2 Tons alcohol synthesis
Tonnes (294.3 g, 1.5 mol, 1.0 eq) and ethanol (1800 mL) were added to a 3 L four-necked flask and stirred at room temperatureAfter dissolving, sodium hydroxide solid (480 g, 12.0 mol, 8.0 eq) was added, and then the temperature was raised to 50 ° C. The reduced Zn(195g, 3.0mol, 2.0eq). After the addition was completed, the mixture was heated to reflux for 4h. The disappearance of the starting material by TLC (VPE / EA = 5: 1)After completion of the reaction, hot filtered to remove the solid, and then concentrated under reduced pressure to remove most of the ethanol, the residue was added 6mol / L dilute hydrochloric acidAdjust the pH = 7, the solid precipitated, filtered, vacuum dried at 50 ° C to give 279g tyl alcohol, the yield was 94%
References:
CN107353275,2017,A Location in patent:Paragraph 0035; 0036; 0037; 0044; 0045; 0046
