Xanthone synthesis
- Product Name:Xanthone
- CAS Number:90-47-1
- Molecular formula:C13H8O2
- Molecular Weight:196.2
Yield:90-47-1 76%
Reaction Conditions:
with palladium diacetate;potassium carbonate;catacxium A in N,N-dimethyl-formamide at 120; for 12 h;Schlenk technique;Inert atmosphere;
Steps:
General procedure for the synthesis of xanthone
General procedure: To an oven-dried 25 mL Schlenk tube containing a stirring bar was added 4.5 mg Pd(OAc)2 (0.02 mmol), 15.7mg nBuPAd2 (0.44 mmol), 2-bromofluorobenzene (0.50 mmol), salicylaldehyde (0.50 mmol), potassium carbonate (1.0 mmol). The Schlenk tube was vacuumed and then purged with argon before DMF (2.0 mL) was injected using a syringe. Afterwards the Schlenk tube in the ice bath was degassed by evacuation and back fillingwith argon three times. The reaction mixture was then stirred for 12 h at 120 °C. After the reaction was complete,the reaction mixture was diluted with water (5 mL), extracted with ethyl acetate (3 x 10 mL) and dried withanhydrous Na2SO4. After filtration and addition of silica gel into the solution, the organic solvent was reduced evaporated. The crude product was purified by column chromatography using ethyl acetate/n-pentane.
References:
Shen, Chaoren;Wu, Xiao-Feng [Synlett,2016,vol. 27,# 8,art. no. ST-2015-B0915-L,p. 1269 - 1273] Location in patent:supporting information
92-83-1
157 suppliers
$20.00/1g
90-47-1
272 suppliers
$14.00/5g
90-46-0
187 suppliers
$25.00/5G
90-47-1
272 suppliers
$14.00/5g
