一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List (S,S,S)-2-Azabicyclo[3,3,0]-octane-carboxylic acid benzylester hydrochloride
93779-31-8

(S,S,S)-2-Azabicyclo[3,3,0]-octane-carboxylic acid benzylester hydrochloride synthesis

1synthesis methods
Cyclopenta[b]pyrrole-2-carboxylic acid, octahydro-, phenylmethyl ester, (2S,3aS,6aS)-, (αS)-α-hydroxybenzeneacetate (1:1)

135214-79-8
0 suppliers
inquiry

-

Yield:-

Reaction Conditions:

with sodium hydroxide in dichloromethane;water at 0 - 3; for 0.25 - 1 h;Product distribution / selectivity;

Steps:

3; 4
55 g of the S,S,S -diastereomeric salt of 2-azabicyclo[3,3,0]-octane-carboxylic acid benzyl ester of Formula III was taken into a round bottom flask containing 450 ml of dichloromethane. The mixture was stirred for 10 minutes at 25° C. A solution of 11.2 g of sodium hydroxide in 45 ml of water was added to the above reaction mass at 0-3° C. The reaction mixture was maintained at 0-3° C. for 15 minutes, and then the organic layer was separated. The resultant aqueous layer was washed with 165 ml of dichloromethane in three equal lots. The pH of the aqueous layer was adjusted to 2.5 using 15.4 ml of aqueous hydrochloric acid. The resultant reaction solution was stirred for about 3 hours at 0-3° C. The separated solid was filtered and washed with 110 ml of dichloromethane, and the wet solid was dried at 65° C. under a vacuum of 350 mm Hg for 7 hours to afford 36.2 g of title compound. Purity by HPLC: 100%; 64.5 kg of the compound obtained in Example 2 was added to a reactor containing 322 liters of dichloromethane. The mixture was stirred for 10 minutes and then cooled to 2° C. A solution of 13.12 kg of sodium hydroxide flakes in 53.8 liters of water was added to the above mixture at 2 to 3° C. and the reaction mass was stirred at the same temperature for one hour. The organic layer was separated and the aqueous layer was extracted into 3×64.5 liters of dichloromethane. The combined organic layer was taken into another reactor and 15.7 liters of 36% aqueous hydrochloric acid was added at 2 to 3° C. The reaction mass was maintained at 2 to 3° C. for 2 hours. The separated solid was filtered and washed with 64.5 liters of chilled dichloromethane. The wet solid was dried at 62° C. for 2 hours to yield 43 kg of the title compound. Purity by HPLC: 99.93%.

References:

Bolugoddu, Vijayabhaskar;Mamilla, Srinivas Reddy;Golla, Chinamala Kondaiah;Madduri, Srinivasa Reddy;Kodipyaka, Ravinder;Das, Surajit;Bhushan, Indu;Mohan, Mailatur Sivaraman US2007/232680, 2007, A1 Location in patent:Page/Page column 11

(S,S,S)-2-Azabicyclo[3,3,0]-octane-carboxylic acid benzylester hydrochloride Related Search:

平陆县| 绥化市| 安塞县| 巴中市| 开阳县| 湖北省| 永仁县| 长葛市| 盱眙县| 隆德县| 定襄县| 称多县| 合江县| 福州市| 平顶山市| 县级市| 高唐县| 玉屏| 政和县| 盐源县| 阿坝| 太谷县| 琼海市| 措勤县| 承德市| 宜君县| 抚州市| 尚志市| 黑河市| 图片| 绿春县| 中宁县| 鄢陵县| 泰顺县| 阿鲁科尔沁旗| 奎屯市| 中阳县| 二连浩特市| 池州市| 都兰县| 温州市|