一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
960067-33-8

2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane synthesis

3synthesis methods
2-(DIFLUOROMETHOXY)BROMOBENZENE

175278-33-8

Bis(pinacolato)diboron

73183-34-3

2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

960067-33-8

The general procedure for the synthesis of 2-difluoromethoxyphenylboronic acid pinacol ester from o-bromodifluoromethoxybenzene and bis(pinacolato)diboron (1.71 g, 6.75 mmol) was carried out as follows: o-bromodifluoromethoxybenzene (1 g, 4.5 mmol) and bis(pinacolato)diboron (1.71 g, 6.75 mmol) were dissolved in dioxane (10 mL), and followed by addition of anhydrous potassium acetate (1.1 g, 13.53 mmol ) and [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium dichloromethane complex (369 mg, 0.45 mmol). The reaction mixture was heated to 85 °C under nitrogen protection and stirred continuously for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure. The residue was purified by silica gel column chromatography with an eluent ratio of petroleum ether: ethyl acetate = 10:1, resulting in the light yellow oily product 2-difluoromethoxyphenylboronic acid pinacol ester (1.1 g, 90.2% yield).

-

Yield: 90.2%

Reaction Conditions:

with dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;potassium acetate in 1,4-dioxane at 85; for 16 h;Inert atmosphere;

Steps:

10 Synthesis of Compound 10-a
2-Bromodifluoromethylphenylether (1 g, 4.5 mmol) and bis(pinacolato)diboron (1.71 g, 6.75 mmol) were dissolved in dioxane (10 mL), and anhydrous potassium acetate (1.1 g, 13.53 mmol) and [1,1'-bis (diphenylphosphino)ferrocene]dichloropalladium.dichloromethane (369 mg, 0.45 mmol) were added.
Under nitrogen gas atmosphere, the mixture was heated to 85° C. and stirred for 16 hours.
After cooling to room temperature, the reaction was concentrated under reduced pressure.
The residue was purified by silica gel column chromatography (petroleum ether: ethyl acetate=10:1) to give 10-a as a pale yellow oil (1.1 g, yield 90.2%).

References:

GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.;XU, Zusheng;ZHANG, Nong;WANG, Tinghan;SUN, Qingrui;WANG, Yuguang US2018/208604, 2018, A1 Location in patent:Paragraph 0216-0217

2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Related Search:

无极县| 新兴县| 紫金县| 海城市| 武威市| 南昌市| 临沧市| 曲沃县| 南京市| 望谟县| 鄂托克前旗| 阳东县| 彝良县| 津市市| 元阳县| 额济纳旗| 娱乐| 昭觉县| 江川县| 武汉市| 上饶县| 五家渠市| 富民县| 威信县| 弥渡县| 三门峡市| 若羌县| 武清区| 新闻| 蒙城县| 祁东县| 哈密市| 和田市| 濉溪县| 界首市| 全南县| 鹤峰县| 介休市| 铜川市| 潜江市| 宜君县|