acepromazine synthesis
- Product Name:acepromazine
- CAS Number:61-00-7
- Molecular formula:C19H22N2OS
- Molecular Weight:326.46
Yield: 22%
Reaction Conditions:
Stage #1:2-acetylphenothiazine with sodium hydride in N,N-dimethyl-formamide at 20; for 0.5 h;
Stage #2:3-(Dimethylamino)propyl chloride in N,N-dimethyl-formamide at 50; for 5 h;
Steps:
General procedure for the synthesis of phenothiazine derivatives 17-21
General procedure: To a solution of 2-acetylphenothiazine (1 mmol) inanhydrous DMF (12 mL) was added NaH (4.5 eq) in portions, and the mixture wasstirred for 30 min at room temperature. Then, the correspondingchloro-derivatives 77-81 were added, and the mixture wasstirred for 5 hours at 50°C. The solution was then concentratedunder vacuum and the residue was purified through column chromatography(7.3:0.2:2.5:0.02 DCM/ethanol/toluene/NH3).
References:
Bolognesi, Maria Laura;Carloni, Paolo;Colini Baldeschi, Arianna;Gandini, Annachiara;Legname, Giuseppe;Rossetti, Giulia;Salzano, Giulia;Tran, Thanh Hoa;Zaccagnini, Ludovica [European Journal of Medicinal Chemistry,2020,vol. 196] Location in patent:supporting information
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1628-29-1
56 suppliers
$6.00/100mg
61-00-7
22 suppliers
inquiry
92-84-2
551 suppliers
$10.00/5g
61-00-7
22 suppliers
inquiry
6632-11-7
4 suppliers
inquiry
61-00-7
22 suppliers
inquiry