Adenosine synthesis
- Product Name:Adenosine
- CAS Number:58-61-7
- Molecular formula:C10H13N5O4
- Molecular Weight:267.24
1867-73-8
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58-61-7
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Yield:58-61-7 97%
Reaction Conditions:
with benzophenone;Selectfluor in water;acetonitrile; for 5 h;Inert atmosphere;UV-irradiation;Reagent/catalyst;
Steps:
10
Ribonucleoside demethylation of N6-methyladenine by using Benzophenone as photosensitizer under 365nm wavelength UV light and Selectfluor: and then into the reaction tube added the N6-methyladenine Ribonucleoside (0.1mmol, 28.1mg), Selectfluor (0.22mmol, 77.9mg), Benzophenone (0.01mmol, 1.8 mg), under nitrogen protection added 2 ml of H20 / CH3CN (1/1) solution, 303nm wavelength of UV light, stirring 5 hours, add the appropriate amount of sodium bicarbonate to the reaction solution at pH 7, spin dry liquid, after column chromatography (CH2Cl2/MeOH=12/1) separation obtained adenine Ribonucleoside 26mg, yield is 97%.
References:
CN106967068,2017,A Location in patent:Paragraph 0042; 0044; 0046; 0048; 0050; 0052; 0054-0058
3001-45-4
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2946-39-6
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18048-85-6
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7387-57-7
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