Afimoxifene synthesis
- Product Name:Afimoxifene
- CAS Number:68392-35-8
- Molecular formula:C26H29NO2
- Molecular Weight:387.51
103-65-1
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$17.00/25mL
68392-35-8
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$25.00/5mg
Yield:-
Steps:
Multi-step reaction with 5 steps
1.1: potassium tert-butoxide; n-butyllithium; tetramethylethylenediamine / hexane; tetrahydrofuran / 0.5 h / 20 °C
1.2: 97 percent / hexane; tetrahydrofuran / 4.5 h / -78 - 20 °C
2.1: 93 percent / aq. hydrochloric acid / ethanol; CH2Cl2 / Heating
3.1: 90 percent / aq. sodium hydroxide; tetrabutylammonium hydrogen sulfate / 18 h / 20 °C
4.1: 57 percent / boron tribromide / CH2Cl2 / 4.5 h
5.1: 31 percent / tetrahydrofuran / 43 h / 60 °C
References:
Burke, Patrick J.;Koch, Tad H. [Journal of Medicinal Chemistry,2004,vol. 47,# 5,p. 1193 - 1206]
4584-46-7
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$15.50/5g
91221-46-4
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$68.00/2 mg
68392-35-8
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611-99-4
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$6.00/5g
68392-35-8
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124-40-3
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$18.00/100ml
147323-02-2
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68392-35-8
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61002-54-8
16 suppliers
$144.00/100mg
68392-35-8
131 suppliers
$25.00/5mg