一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List AYANIN
572-32-7

AYANIN synthesis

13synthesis methods
-

Yield: 28% , 60%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 25; for 12 h;Inert atmosphere;regioselective reaction;

Steps:

3.1.29. Synthesis of dimethylether 25 and trimethylether 31
To a solution of 1 (151 mg, 0.5 mmol) in dry DMF (20 ml) was added K2CO3 (276 mg, 2.0 mmol, 4.0 equiv.) and iodomethane (0.11 ml, 1.75 mmol, 3.5 equiv.) at room temperature. After 12 h, the reaction mixture was then partitioned between 100 ml ethyl acetate and 100 ml water. The ethyl acetate layer was then washed with brine (100 ml), dried over MgSO4, filtered and concentrated. The crude material was purified by column chromatography (25% ethyl acetate in petroleum ether) to yield 25 (46 mg, 28% yield) and 31 (103 mg, 60% yield) as yellow solids.3.1.30. 3,5-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-4H-chromen-4-one (25)Mp 185-186 °C. 1H NMR (CDCl3, 300 MHz) δ 3.86 (s, 3H, -OCH3), 3.98 (s, 3H, -OCH3), 5.70 (s, 1H, 3'-OH), 6.28 (d, J = 2.0 Hz, 1H, 6-H), 6.41 (d, J = 2.0 Hz, 1H, 8-H), 6.98 (d, J = 8.6 Hz, 1H, 5'-H), 7.68 (d, J = 2.0 Hz, 1H, 2'-H), 7.78 (dd, J = 2.0, 8.6 Hz, 1H, 6'-H), 12.68 (s, 1H, 5-OH). ESI-MS m/z: 331 [M + H]+, 353 [M + Na]+.3.1.31. 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,7-dimethoxy-4H-chromen-4-one (31)Mp 148-149 °C. 1H NMR (CDCl3, 300 MHz) δ 3.87 (s, 6H, -OCH3), 3.99 (s, 3H, -OCH3), 5.70 (s, 1H, -OH), 6.35 (d, J = 2.2 Hz, 1H, 6-H), 6.44 (d, J = 2.2 Hz, 1H, 8-H), 6.96 (d, J = 8.6 Hz, 1H, 5'-H), 7.69 (d, J = 2.0 Hz, 1H, 2'-H), 7.78 (dd, J = 2.0, 8.6 Hz, 1H, 6'-H), 12.63 (s, 1H, 5-OH). ESI-MS m/z: 345 [M + H]+, 367 [M + Na]+.

References:

Shi, Zhi-Hao;Li, Nian-Guang;Tang, Yu-Ping;Wei-Li;Lian-Yin;Yang, Jian-Ping;Hao-Tang;Duan, Jin-Ao [European Journal of Medicinal Chemistry,2012,vol. 54,p. 210 - 222] Location in patent:experimental part

AYANIN Related Search:

嘉兴市| 临漳县| 鸡西市| 微山县| 卢湾区| 永宁县| 若尔盖县| 平和县| 靖宇县| 镇雄县| 石林| 建湖县| 岑巩县| 千阳县| 龙胜| 保定市| 绥宁县| 凤翔县| 师宗县| 屯昌县| 云龙县| 贵港市| 阿图什市| 蓬莱市| 罗山县| 吉首市| 普陀区| 旅游| 荣昌县| 肥城市| 灵丘县| 甘孜县| 清流县| 离岛区| 莱阳市| 关岭| 平阳县| 湄潭县| 外汇| 江源县| 井冈山市|