Betahistine synthesis
- Product Name:Betahistine
- CAS Number:5638-76-6
- Molecular formula:C8H12N2
- Molecular Weight:136.19
100-69-6
210 suppliers
$14.00/1mL
593-51-1
529 suppliers
$21.00/100g
5638-76-6
166 suppliers
$20.00/250mg
Yield:5638-76-6 95%
Reaction Conditions:
in water at 170; under 7500.75 Torr;Temperature;Pressure;Solvent;
Steps:
1-2; 13-46; 1-7
1. Take 15mL of 2-vinylpyridine without dilution; 2. Take methylamine hydrochloride (9.12g, 135mmol), add water to dissolve it until the solution is 15mL, and use this as reaction solution 1 and reaction solution 2 to wait for feeding. . Adjust the back pressure valve to control the pressure of the reaction system to 1.0 MPa, and connect a section of pre-cooling pipeline with a length of 2 m at the front end of the back pressure valve. The temperature of the heater is controlled to reach 170°C, and the two materials are pumped into the microchannel reactor through the mixer. The reaction liquid 1 fluid flows through the microreactor at 0.5 mL/min, and the reaction liquid 2 fluid flows through the microreactor at 0.9 mL/min. The molar ratio of 2-vinylpyridine to methylamine hydrochloride was 1:1.7, the reaction residence time was 1.8min, and the conversion rate of 2-vinylpyridine was 100% and the selectivity was 95%. %, the yield is 95%, and the product is betahistine.
References:
CN113444034,2021,A Location in patent:Paragraph 0046-0052; 0067-0176;
100-69-6
210 suppliers
$14.00/1mL
74-89-5
0 suppliers
$13.44/25ML
5638-76-6
166 suppliers
$20.00/250mg
100-69-6
210 suppliers
$14.00/1mL
6998-30-7
20 suppliers
$35.00/1G
5638-76-6
166 suppliers
$20.00/250mg
![Carbamic acid, N-methyl-N-[2-(2-pyridinyl)ethyl]-, 1,1-dimethylethyl ester](/CAS/20210305/GIF/143185-44-8.gif)
143185-44-8
0 suppliers
inquiry
5638-76-6
166 suppliers
$20.00/250mg
67-56-1
792 suppliers
$9.00/25ml
2706-56-1
300 suppliers
$6.00/1g
5638-76-6
166 suppliers
$20.00/250mg