ChemicalBook CAS DataBase List 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate synthesis

10synthesis methods

Product Name:1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate
CAS Number:203866-14-2
Molecular formula:C10H16FNO4
Molecular Weight:233.24

(2R,4S)-N-BOC-4-fluoro-D-proline is a pharmaceutical intermediate that can be used to prepare NS5A inhibitors. It can be obtained from N-Boc-trans-4-hydroxy-L-proline methyl ester as raw material, firstly fluorinated to obtain N-Boc-trans-4-fluoro-L-proline methyl ester, then hydrolyzed.

203866-18-6 Synthesis

BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER

203866-18-6
143 suppliers
$14.00/250mg

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate

203866-14-2
229 suppliers
$23.30/1G

Yield:-

Steps:

G

The fluorination of the above cis-hydroxy provides the trans-4-fluoro derivative which on saponification gives the corresponding acid. The amine is prepared from 4-R-fluoro-pyrrolidine-1-carboxylic acid tert-butyl ester and 5-methyl-pyridin-2-ylamine under HATU condition to give proline amide derivative which on treatment with 4 M HCl in dioxane provides the desired amine.

References:

US2009/62537,2009,A1 Location in patent:Page/Page column 10

1,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) 2-(phenylmethyl) ester, (2S,4R)-

587887-98-7
2 suppliers
inquiry

203866-14-2
229 suppliers
$23.30/1G

References

132622-90-3
12 suppliers
inquiry

203866-14-2
229 suppliers
$23.30/1G

References

87691-27-8 Synthesis

87691-27-8
244 suppliers
$6.00/250mg

203866-14-2
229 suppliers
$23.30/1G

References

89813-47-8
58 suppliers
$44.60/250mg

203866-14-2
229 suppliers
$23.30/1G

References

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Related Search:

N-BOC-cis-4-fluoro-L-proline (2R,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid N-BOC-4,4-difluoro-L-proline BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER N-Boc-4,4-difluoro-L-proline methyl ester D-Proline L-Proline

HomePage | About Us | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Product Catalog | Links | Privacy | Terms | Product Manufacturers | New Products
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.

一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate synthesis

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Related Search: