ChemicalBook CAS DataBase List D-Proline

D-Proline synthesis

6synthesis methods

Product Name:D-Proline
CAS Number:344-25-2
Molecular formula:C5H9NO2
Molecular Weight:115.13

D-amino acids are an important class of chiral reagents and chiral intermediates. Currently, most of the D-amino acids are produced by synthesizing the racemates and then splitting them to obtain the optical isomers. The asymmetric conversion method, u

23356-96-9 Synthesis

23356-96-9
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344-25-2
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$5.00/250mg

Yield:344-25-2 95.65%

Reaction Conditions:

with potassium permanganate in water at 15 - 20;Concentration;

Steps:

1.2 Step (2) Synthesis of D-valine

50.5 g of the oil intermediate II was added to the flask, and 350 ml of water was added thereto, and the mixture was stirred. When the temperature of the reaction solution was maintained at 15-20 ° C, a solution of 94.8 g of potassium permanganate dissolved in 155 ml of water was added dropwise. After about 1.5-2.5h of addition, the reaction was further incubated for 0.5-1.5h, and the saturated sodium hydrogen sulfite solution was added dropwise until the color of the Potassium permanganate solution disappears; After suction filtration, the filter cake is washed with water, and the filtrate and washing liquid are combined, concentrated to about 100 ml under reduced pressure, adjusted to pH 2 with concentrated hydrochloric acid, concentrated and dried, and then dissolved in methanol and stirred well. The insoluble material was filtered off, and the filtrate was concentrated to dryness and then recrystallized from acetone to obtain 55 g of D-Proline. The yield was 95.65% and the ee value was 99%.

References:

CN107827802,2018,A Location in patent:Paragraph 0026; 0030-0032; 0035