Bumetanide synthesis
- Product Name:Bumetanide
- CAS Number:28395-03-1
- Molecular formula:C17H20N2O5S
- Molecular Weight:364.42
28328-54-3
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$190.00/y0000310
71-36-3
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$14.00/25mL
28395-03-1
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$35.00/500mg
Yield:28395-03-1 95.8%
Reaction Conditions:
with iron(III) chloride;boron trifluoride diethyl etherate at 20; for 6 h;Reagent/catalyst;
Steps:
4 Example 4
0.1 mol of 3-amino-4-phenoxy-5-sulfonamide benzoic acid was added to the reaction flask, and then 500 ml of n-butanol was added and stirred at room temperature. To the reaction flask, 5 mmol of boron trifluoride diethyl ether and 5mmol ferric chloride, the reaction 6 hours until the reaction is complete, stop stirring,After most of the n-butanol was distilled off from the reaction mixture, 200 ml of 2 M sodium hydroxide solution and 100 ml were addedEthanol was heated to reflux for 30 minutes, then add concentrated hydrochloric acid to adjust the pH to 8-8.2, cooled, standing, suction filtration, filtration, the filter cake plus water and heated to dissolve, add a small amount of activated carbon decolorization,After filtration, the sodium salt was precipitated by cooling and after filtration, 300 ml of water was added into the solution to dissolve it,Then add concentrated hydrochloric acid to pH2-3, cooling, suction filtration, washing and drying to obtain a pure product of bumetanide,Yield 95.8%, purity 99.4%.
References:
Zaozhuang Run'an Pharmaceutical New Materials Co., Ltd.;Zhang Fengzhi CN106748906, 2017, A Location in patent:Paragraph 0015; 0016; 0017; 0018; 0019
32643-00-8
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$495.77/5MG
28395-03-1
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$35.00/500mg
28510-66-9
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28395-03-1
337 suppliers
$35.00/500mg