4-Dimethylaminobenzoic acid synthesis
- Product Name:4-Dimethylaminobenzoic acid
- CAS Number:619-84-1
- Molecular formula:C9H11NO2
- Molecular Weight:165.19
a, weigh 1g of ethyl p-aminobenzoate in a two-port round-bottomed flask, add 40 ml of acetone to dissolve, then add 3.6g of anhydrous potassium carbonate and 14.1g of iodomethane, the reaction under nitrogen protection at 80 ℃ stirring reflux for 24 ho
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Yield:619-84-1 90%
Reaction Conditions:
with C26H30B10Cl2P2Pd in toluene at 50; under 760.051 Torr; for 8 h;
Steps:
5 Catalytic synthesis of carboxylic acids with palladium complexes
In a reaction tube, dissolve palladium complex [Pd] (0.02 mmol) and p-dimethylaminobromobenzene (1.0 mmol) in 3 mL of toluene,extract and ventilate three timesin a CO2atmosphere, and connect a CO2balloonunder normal pressure. The reaction was performed at 50 ° C for 8 hours. After the reaction, the reaction mixture was acidified. The reaction solution was concentrated and separated by column chromatography to obtain the corresponding product C9H11NO2(yield 90%).
References:
Shanghai Institute of Technology;Yao Zijian;Chen Jing CN110483581, 2019, A Location in patent:Paragraph 0047-0050
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