CHOLESTERYL CHLOROACETATE synthesis
- Product Name:CHOLESTERYL CHLOROACETATE
- CAS Number:3464-50-4
- Molecular formula:C29H47ClO2
- Molecular Weight:463.14
57-88-5
887 suppliers
$10.00/1g
79-04-9
377 suppliers
$12.00/5g
3464-50-4
21 suppliers
$172.00/100mg
Yield:3464-50-4 98%
Reaction Conditions:
with triethylamine in dichloromethane at 20;
Steps:
chloroacetic acid cholesterylester (1): Slowly add a solution of 9.54 ml (120 mmol) chloroacetylchloride in 50 ml dichloromethane in drops to a solution of 38.67 g (100 mmol) cholesterol and 20.79 ml (150 mmol) triethylamine in 150 ml dichloromethane under refrigeration.Stir the formulation overnight at room temperature and then extract twice with 100 ml 2 N HCl each time.Remove the solvent and stir the residue in 200 ml dichloromethane with 5 g activated charcoal at room temperature.Filter off the activated charcoal, remove the solvent, and purify the residue via column chromatography on 50 g silica gel (dichloromethane).The yield is 45.04 g 1 as a colorless solid.
References:
US2003/229037,2003,A1 Location in patent:Page/Page column 37-38, 7
57-88-5
887 suppliers
$10.00/1g
541-88-8
162 suppliers
$10.00/5g
3464-50-4
21 suppliers
$172.00/100mg
57-88-5
887 suppliers
$10.00/1g
79-04-9
377 suppliers
$12.00/5g
3464-50-4
21 suppliers
$172.00/100mg