7H-Pyrrolo[2,3-d]pyrimidine synthesis
- Product Name:7H-Pyrrolo[2,3-d]pyrimidine
- CAS Number:271-70-5
- Molecular formula:C6H5N3
- Molecular Weight:119.12
![4-Chloro-7H-pyrrolo[2,3-d]pyrimidine](/CAS/GIF/3680-69-1.gif)
3680-69-1
271-70-5
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine (compound 1001) (130 mg, 0.847 mmol) was used as a raw material and dissolved in 3 mL of methanol. The hydrogenation reaction was carried out by adding 10% Pd-C catalyst under hydrogen atmosphere at 1 atmosphere for 16 hours. Upon completion of the reaction, the reaction solution was concentrated to dryness to afford 7H-pyrrolo[2,3-d]pyrimidine (Compound 1002) in 100 mg yield and 98% yield. The product was characterized by 1H-NMR (CD3OD): δ 9.4 (s, 1H); 9.1 (s, 1H); 7.9 (s, 1H); 7.1 (s, 1H).
3680-69-1
841 suppliers
$6.00/1g
271-70-5
193 suppliers
$8.00/100mg
Yield:271-70-5 98%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in methanol under 760.051 Torr; for 16 h;
Steps:
1a; 1.i
As shown in Figure 1-step i, 4-chloro-7H-pyrrolo[2,3-d]pyrimidine(compound 1001) (130 mg, 0.847 mmol) was dissolved in 3 mL of methanol and hydrogenated under 1 atm of hydrogen over Pd-C 10% for 16 hours. Concentration to dryness provided 100 mg (98%) of 7H-pyrrolo[2,3-d ]pyrimidine [compound 1002, 1H-NMR(CD3OD): δ 9.4 (s, IH); 9.1 (s, IH); 7.9 (s, IH); 7.1 (s, IH)].
References:
VERTEX PHARMACEUTICALS INCORPORATED WO2007/41130, 2007, A2 Location in patent:Page/Page column 40; Sheet 1/9
530-91-6
98 suppliers
$15.00/100mg
3680-69-1
841 suppliers
$6.00/1g
271-70-5
193 suppliers
$8.00/100mg
![4H-Pyrrolo[2,3-d]pyrimidine-4-thione,3,7-dihydro-](/CAS/20180527/GIF/1421-27-8.gif)
1421-27-8
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271-70-5
193 suppliers
$8.00/100mg
![Pyrrolo[2,3-d]pyrimidin-4-ol](/CAS/GIF/3680-71-5.gif)
3680-71-5
420 suppliers
$6.00/1g
271-70-5
193 suppliers
$8.00/100mg