N-Hydroxysuccinimide synthesis
- Product Name:N-Hydroxysuccinimide
- CAS Number:6066-82-6
- Molecular formula:C4H5NO3
- Molecular Weight:115.09
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Yield:6066-82-6 98.2%
Reaction Conditions:
with chitosan in aq. phosphate buffer;dichloromethane at 50; for 5 h;Microwave irradiation;Solvent;Temperature;
Steps:
2 Example 2
Adding 16.12g of chitosan and 57g of N-hydroxysuccinimidyl-4-azidobenzoate to the reactor, adding 70g of PBS buffer and 300mL of dichloromethane solvent, stirring and mixing evenly Then, put it into the microwave reactor, put the temperature sensor into the reaction liquid, then turn on the magnetic stirring, adjust the stirring speed to make the stirrer rotate stably in the solution, then close the door of the microwave reactor, and set the reaction temperature to 50 ° C, and set the reaction time is 5 hours, the reaction is carried out under microwave heating assisted conditions, the reaction time is reached after the mega-reaction time reaches the set time, the sample is confirmed to be complete, and then slowly cooled to room temperature, stirred for 30 min, suction filtration A dichloromethane solution containing N-hydroxysuccinimide was obtained, wherein 22.60 g of N-hydroxysuccinimide was obtained in a yield of 98.2%, and the purity was 99.6%. Here, the solvent can be removed by a general method, and the product N-hydroxysuccinimide can be isolated, or the N-hydroxysuccinimide-containing DMF solution can be directly used for the next reaction.
References:
CN108440366,2018,A Location in patent:Paragraph 0016; 0023-0032
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