N-Iodosuccinimide synthesis
- Product Name:N-Iodosuccinimide
- CAS Number:516-12-1
- Molecular formula:C4H4INO2
- Molecular Weight:224.98
The finely powdered salt (49.5g) was added in portions with stirring to a solution of 50.8g of iodine in 300ml of acetone, the temperature being maintained at 5-10°C. After decolorization (30 min.), the silver iodide was filtered, the solvent was removed under reduced pressure at room temperature and the residue was washed with ether, yielding 43g of N-iodosuccinimide with mp 189-191°C. An analytical sample (85% recovery) was obtained by dissolving in the minimum quantity of hot dioxane and precipitating with carbon tetrachloride; colorless needles, mp 200-201°C.
Ref: JACS 75, 3493 (1953)
123-56-8
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516-12-1
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Yield:516-12-1 99%
Reaction Conditions:
with [bis(acetoxy)iodo]benzene;iodine in benzene at 20; for 15 h;Darkness;Concentration;Solvent;Time;
Steps:
4 Preparation of N-iodosuccinimide in benzene
[00172] A mixture of succinimide (1.0 g, 10.1 mmol), PhI(OAc)2 (1.95 g, 6.06 mmol), I2 (1.67 g, 6.57 mmol) and benzene (20 mL) was stirred for 15 h at rt and for 1 h at 0 to 5 °C. The precipitated solid was filtered, washed on the filter with cold benzene and dried in vacuo to give 2.2 g (99%) of N-iodosuccinimide.
References:
WO2015/68159,2015,A2 Location in patent:Paragraph 00171-00172
128-09-6
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516-12-1
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128-08-5
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516-12-1
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7553-56-2
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67-64-1
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516-12-1
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