Dextromethorphan synthesis
- Product Name:Dextromethorphan
- CAS Number:125-71-3
- Molecular formula:C18H25NO
- Molecular Weight:271.4
6700-34-1
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125-71-3
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Yield:125-71-3 97.98%
Reaction Conditions:
with sodium hydroxide in chloroform;water; for 0.5 h;
Steps:
Demethylation of DM
A solution of 2.68 g (67 mmol) of sodium hydroxide in 50 ml of water was added to a solution of 25 g (67 mmol) of dextromethorphan hydrobromide hydrate in 100 ml of chloroform.
The reaction mixture was stirred for 30 min on a magnetic stirrer.
The organic layer was separated and dried with anhydrous sodium sulfate.
The solvent was evaporated on a rotavap.
The obtained freebase of dextromethorphan was a dense and viscous off-white oil which solidified upon standing. Yield: 17.95 g (97.98%).
References:
Jozwiak, Krzysztof;Targowska-Duda, Katarzyna M.;Kaczor, Agnieszka A.;Kozak, Joanna;Ligeza, Agnieszka;Szacon, Elzbieta;Wrobel, Tomasz M.;Budzynska, Barbara;Biala, Grazyna;Fornal, Emilia;Poso, Antti;Wainer, Irving W.;Matosiuk, Dariusz [Bioorganic and Medicinal Chemistry,2014,vol. 22,# 24,p. 6846 - 6856]
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67596-84-3
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104-01-8
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51072-35-6
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51072-34-5
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