DI-P-TOLYLMETHANE synthesis
- Product Name:DI-P-TOLYLMETHANE
- CAS Number:4957-14-6
- Molecular formula:C15H16
- Molecular Weight:196.29
Yield: 92%
Reaction Conditions:
with C23H40Br2N2NiO5P;magnesium in tetrahydrofuran at 50; for 10 h;Inert atmosphere;
Steps:
25 Example 25: Reduction cross-coupling reaction of p-methylfluorobenzene and p-methylchlorobenzyl catalyzed by Ni(NHC)[P(OR)3]X2 (R = CH2CH3, X = Br) as catalyst
Under the protection of argon gas, the catalyst (6.8 mg, 0.010 mmol, 2 mol%), magnesium dust (14.5 mg, 0.6 mmol), andP-methylfluorobenzene (55 μl, 0.5 mmol), p-methylchlorobenzyl (80 μl, 0.6 mmol), tetrahydrofuran (1.0 mL) as a solvent, and react at 50 oC for 10 hours, The reaction was terminated with a saturated ammonium chloride solution. The reaction product was extracted with ethyl acetate and purified by column chromatography (with petroleum ether as the developing solvent) with a yield of 92%.
References:
Soochow University (Suzhou);Sun Hongmei;Shen Zhengwang CN110305171, 2019, A Location in patent:Paragraph 0073-0074
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