diethyl 2-acetamido-2-phenethyl-propanedioate synthesis
- Product Name:diethyl 2-acetamido-2-phenethyl-propanedioate
- CAS Number:5463-92-3
- Molecular formula:C17H23NO5
- Molecular Weight:321.38
15121-91-2
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5463-92-3
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$215.25/250mg
Yield: 72.1%
Reaction Conditions:
with perchloric acid;palladium on activated charcoal;hydrogen in ethanol;water
Steps:
1.c c. Synthesis of 2-acetylamino-2-phenethylmalonic acid diethyl ester (Compound 15):
10.0 g of compound 14 was dissolved in ethanol (100 mL),Add 1.0 g of palladium-carbon and 0.1 mL of aqueous perchloric acid.Medium pressure hydrogenation reaction for 48-72 hours.After the reaction is completed, it is filtered through celite and the reaction solution is distilled off.The crude compound 15 obtained. The crude product was recrystallized using 50% methanol-water.The crystals were crystallized in an ice bath for 2 hours and filtered to obtain purified compound 15, with a yield of 72.1%.
References:
Chinese Academy Of Medical Sciences Pharmaceutical Institute;Shi Zeyu;Chen Si;Xiao Qiong;Zhang Xiang;Tian Yulin;Yin Dali CN111087357, 2020, A Location in patent:Paragraph 0064-0066; 0069
103-63-9
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1068-90-2
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5463-92-3
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17376-04-4
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1068-90-2
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5463-92-3
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71-43-2
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5463-92-3
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532-27-4
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5463-92-3
45 suppliers
$215.25/250mg