(2-Bromoethyl)benzene synthesis
- Product Name:(2-Bromoethyl)benzene
- CAS Number:103-63-9
- Molecular formula:C8H9Br
- Molecular Weight:185.06
Reaction: The phenethyl alcohol was heated to 110°C, hydrogen bromide was slowly introduced, and the reaction was refluxed. The reaction was completed, cooled, washed with water, 10% sodium carbonate solution, and water in turn. After drying with anhydrous potassium carbonate, fractional distillation under reduced pressure was carried out to collect fractions at 97-99°C (2.0 kPa) with a yield of over 90%.
60-12-8
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103-63-9
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Yield:103-63-9 97%
Reaction Conditions:
with 1,2-dibromo-1,1,2,2-tetrachloroethane;triphenylphosphine in dichloromethane at 20; for 0.15 h;Appel Halogenation;
Steps:
3.3. General procedure for conversion to bromide
General procedure: PPh3 (2.2 mmol) was dissolved in freshly distilled dichloromethane (4.0 mL) at 20 °C. A solution of DBTCE (2.2 mmol) in freshly distilled dichloromethane (4.0 mL) was added to the solution dropwise and the white colloidal mixture was stirred for 2 min. A solution of alcohol (2.0 mmol) or cyclic ether (1.0 mmol) in freshly distilled dichloromethane (4.0 mL) was added to the mixture dropwise over 2 min and during adding the reaction mixture became a colorless solution. The resulting solution was stirred for 5 min and the mixture was purified by flash column on 20 g of silica gel using petroleum ether or a mixture of petroleum ether/EtOAc (1:1).
References:
Essiz, Sel?uk;Da?tan, Arif [Turkish Journal of Chemistry,2019,vol. 43,# 1,p. 150 - 156]
165904-22-3
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103-63-9
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100-42-5
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103-63-9
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458-87-7
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103-63-9
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108-88-3
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74-95-3
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1081-75-0
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103-63-9
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103-29-7
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