Phenethyl alcohol synthesis
- Product Name:Phenethyl alcohol
- CAS Number:60-12-8
- Molecular formula:C8H10O
- Molecular Weight:122.16
98-86-2
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60-12-8
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Yield:60-12-8 100%
Reaction Conditions:
with potassium tert-butylate;hydrogen in ethanol at 40; under 7600.51 Torr; for 19 h;Autoclave;Inert atmosphere;Solvent;
Steps:
1 Hydrogenation of acetophenone
Acetophenone used a Kanto Chemical Co., Ltd. reagent special grade grade directly. In an autoclave, RuBr2 [(S,S)-xylskewphos] (3,5-Me2pica) 1.32 mg (1.29 × 10 -3 mmol, S / C = 10000) and potassium tert-butoxide 5.79 mg (5.16) × 10 -2 mmol) was charged and replaced with argon gas.Under argon gas flow, 1.5 mL (12.9 mmol) of acetophenone and 2.9 mL of ethanol were metered with a syringe, pressurized to 10 atm with hydrogen, and stirred at 40 ° C. for 19 hours. As a result, phenylethanol was obtained in 100% yield.In addition, GC (CP-Chirasil-DEX CB (0.25 mm ID × 25 m, DF = 0.25 μm, VARIAN)) 110 ° C. constant, pressure 102.0 kPa, column flow 1.18 mL / min, vaporization chamber temperature 250 ° C,The optical purity was measured with a detector temperature of 275 ° C., retention time of each enantiomer: (R): 11.7 min, (S): 12.4 min, and it was 88.0% ee, (S) The body was generating preferentially.
References:
JP2019/11367,2019,A Location in patent:Paragraph 0105; 0108; 0111-0112
93-56-1
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82529-79-1
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60-12-8
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78926-09-7
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103-82-2
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60-12-8
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