Dimethyl aminoterephthalate synthesis
- Product Name:Dimethyl aminoterephthalate
- CAS Number:5372-81-6
- Molecular formula:C10H11NO4
- Molecular Weight:209.2
5292-45-5
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$6.00/5g
5372-81-6
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Yield:5372-81-6 99.1%
Reaction Conditions:
with iron;ammonium chloride in ethanol;water; for 0.5 h;Reflux;Solvent;
Steps:
1.2
Nitro Reduction: To 50ml volume ratio of 1: 1 ethanol / water solution of ammonium chloride was added 2.3g, iron 2.3g, stirred heated to reflux for 30min; 2-nitro-dimethyl terephthalate (ie, compound II ) 10.0 g was dissolved in 25ml of ethanol, was added dropwise to the reaction flask slowly (to prevent the red material), after the addition was complete the reaction was continued at this temperature for 30min, TLC monitored the reaction was complete; cooled to room temperature, filtered through celite pad, the cake washed with until no product was adsorbed was washed with ethanol, and concentrated under reduced pressure to remove ethanol; aqueous layer was washed with saturated Na2CO3Solution was adjusted pH10, 50mlEA aqueous phase was extracted twice, the combined organic phase was washed by saturated sodium chloride, dried over anhydrous sodium sulfate, and evaporated to dryness to give 8.7g solid, i.e., 2-amino dimethyl terephthalate (i.e. compound III ), shown in Figure 2, a yield of 99.1%,
References:
CN104072403,2016,B Location in patent:Paragraph 0034
67-56-1
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10312-55-7
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5372-81-6
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120-61-6
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5372-81-6
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$17.67/5gm:
10312-55-7
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$7.00/1g
5372-81-6
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$17.67/5gm:
60728-41-8
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$46.00/5g
5372-81-6
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$17.67/5gm: