Ebselen synthesis
- Product Name:Ebselen
- CAS Number:60940-34-3
- Molecular formula:C13H9NOSe
- Molecular Weight:274.18
1502-47-2
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60940-34-3
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$17.00/5mg
Yield:60940-34-3 91%
Reaction Conditions:
with selenium;hydrazine hydrate;lithium hydroxide in N,N-dimethyl-formamide; for 20 h;Inert atmosphere;Heating;
Steps:
Method B.
General procedure: Hydrazine hydrate (8.0 mmol) was added dropwise to the mixture of selenium powder (1.2 mmol) and lithium hydroxide (3.6 mmol) in DMF (3 mL). Reaction was heated to 120 oC and stirred for 15 min under argon atmosphere. After cooling to room temperature the amide (1.0 mmol) in DMF (2 mL) was added. The reaction mixture was heated to 120 oC and stirred for 20 h under argon atmosphere. The solution was cooled, 25 mL of brine was added and the mixture was stirred for additional 20h. Precipitate was filtered under vacuum, washed with water and dried in air. The crude product was purified by column chromatography (silica gel, DCM:MeOH 99.2 : 0.8). Yields: 91% 1, 86% 9, 60% 10, 67% 11, 72% 12, 82% 13, 75% 14.
References:
Pacu?a, Agata J.;Obieziurska, Magdalena;?cianowski, Jacek;Kaczor, Katarzyna B.;Antosiewicz, J?drzej [Arkivoc,2018,vol. 2018,# 3,p. 153 - 164]
6833-13-2
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$50.00/250mg
60940-34-3
262 suppliers
$17.00/5mg
93-98-1
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$15.00/5mg
60940-34-3
262 suppliers
$17.00/5mg
106663-84-7
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60940-34-3
262 suppliers
$17.00/5mg