Efavirenz synthesis
- Product Name:Efavirenz
- CAS Number:154598-52-4
- Molecular formula:C14H9ClF3NO2
- Molecular Weight:315.67
102-09-0
406 suppliers
$6.00/25g
209414-27-7
130 suppliers
$55.00/10 mg
154598-52-4
498 suppliers
$25.00/1g
Yield:154598-52-4 98%
Reaction Conditions:
with 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran at 20 - 60; for 2 h;
Steps:
2
EXAMPLE-2 Preparation of Efavirenz From (S)-Amino Alcohol by Using Diphenylcarbonate: 1.5 g of (S)-amino alcohol (5.19 mmol) was dissolved in THF (20 ml) and DBU (1.7 ml, 11.42 mmol) was added at room temperature. Then diphenylcarbonate (4.443 g, 19.38 mmol) was added and the mixture was further stirred at 60° C. for 2h. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was successively washed with aqueous hydrochloric acid, DM water and brine, concentrated and purified on silica gel column chromatography to get 90-98% yield of pure Efavirenz (HPLC purity=99.7%).
References:
LUPIN LIMITED US2012/108809, 2012, A1 Location in patent:Page/Page column 2-3
1381993-90-3
1 suppliers
inquiry
154598-52-4
498 suppliers
$25.00/1g
32315-10-9
438 suppliers
$10.00/1g
209414-27-7
130 suppliers
$55.00/10 mg
503-38-8
129 suppliers
$15.00/5g
154598-52-4
498 suppliers
$25.00/1g
1381993-90-3
1 suppliers
inquiry
154801-74-8
50 suppliers
inquiry
154598-52-4
498 suppliers
$25.00/1g
209414-27-7
130 suppliers
$55.00/10 mg
105-58-8
484 suppliers
$14.00/25g
154598-52-4
498 suppliers
$25.00/1g