Eletriptan hydrobromide synthesis
- Product Name:Eletriptan hydrobromide
- CAS Number:177834-92-3
- Molecular formula:C22H27BrN2O2S
- Molecular Weight:463.43
143322-58-1
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177834-92-3
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Yield:177834-92-3 98.34%
Reaction Conditions:
with hydrogen bromide in acetone at 20; for 0.25 h;Product distribution / selectivity;
Steps:
17
Example 17; Preparation of Eletriptan-HBr from Eletriptan-Base49% w/w Hydrobromic acid (2.13 g, 0.0262 mol) was added to a stirred solution of the oil obtained in Example 16 (5.0 g, 0.0130 mol) in acetone (50 mL) at room temperature. After 15 minutes, the reaction mixture was evaporated under reduced pressure to give a yellow liquid. The water remaining in this yellow liquid was then azeotropically removed using 2-propanol. The resulting cloudy, yellowish oil (7.2 g) was triturated with ether and then dissolved in hot 2-propanol (125 mL). This solution, on cooling, provided the title compound (5.95 g) as a pale yellow crystalline solid after filtration. The filtered solid was washed with 2-propanol and dried under vacuum. (purity 99.78%, yield 98.34%, Assay 10.9%, water by KF 3.41%) m.p. 170.8-172.9° C.
References:
KANSAL, Vinod Kumar;MISTRY, Dhirenkumar N.;PATEL, Rakesh Ravjibhai;PANDEY, Saurabh US2009/299077, 2009, A1 Location in patent:Page/Page column 8
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180637-89-2
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177834-92-3
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177834-92-3
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177834-92-3
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