ChemicalBook CAS DataBase List Enrofloxacin

Enrofloxacin synthesis

12synthesis methods

Product Name:Enrofloxacin
CAS Number:93106-60-6
Molecular formula:C19H22FN3O3
Molecular Weight:359.39

5308-25-8

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

86393-33-1

93106-60-6

The reaction was carried out with 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (1a, 1 mmol) and N-ethylpiperazine (2y, 1.5 mmol) by adding n-FZSA (0.06 g) as a catalyst, and the reaction was heated under reflux conditions in H2O (5 ml). The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the catalyst was separated using an external magnet and washed with hot ethanol (5 mL). Subsequently, the reaction mixture was cooled to room temperature. The precipitated solid was collected by filtration and recrystallized with methanol to afford the target product 1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid in a high yield of 96%.

5308-25-8 Synthesis

5308-25-8
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$15.00/5G

86393-33-1 Synthesis

86393-33-1
354 suppliers
$15.00/25g

93106-60-6
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$6.00/1g

Yield:93106-60-6 97%

Reaction Conditions:

with nano iron oxide on ZrO₂ coated sulfonic acid in water; for 0.316667 h;Reflux;Solvent;Temperature;Reagent/catalyst;

Steps:

3.2. General Experimental Procedure

A mixture of 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 1a (1 mmol) and Nethylpiperazine2y (1.5 mmol) and n-FZSA (0.06 g) as catalystin H2O (5 ml) were heated under reflux for the appropriatetime. The reaction was monitored by TLC. After appropriatetime, the catalyst was separated using an externalmagnet and washed with hot ethanol (5 mL). The reactionmixture was then cooled to room temperature. The precipitatedsolid was collected by filtration, and recrystallized fromethanol 96% to give desired compound in high yields.

References:

Nakhaei, Ahmad;Ramezani, Shirin;Shams-Najafi, Sayyed Jalal;Farsinejad, Sadaf [Letters in Organic Chemistry,2018,vol. 15,# 9,p. 739 - 746]

5308-25-8 Synthesis

5308-25-8
462 suppliers
$15.00/5G