Erlotinib synthesis
- Product Name:Erlotinib
- CAS Number:938185-06-9
- Molecular formula:C16H11N3O2
- Molecular Weight:277.28
![6,7-Quinazolinediol, 4-[(3-ethynylphenyl)amino]-, 6,7-diacetate](/CAS/20210305/GIF/938185-10-5.gif)
938185-10-5
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Yield:938185-06-9 100%
Reaction Conditions:
with ammonium hydroxide in methanol at 20;
Steps:
9.5 Synthesis of 6,7-dihydroxy-4-anilinoquinazoline
3 g of the resulting product 6,7-diacetoxyl-4-anili- noquinazoline obtained in step 4 was dissolved in 40 ml of methanol, and then the mixture was added with 5 ml of aqua ammonia. The system was reacted at room temperature, and followed by TLC until the reaction finished. The reaction solution was concentrated in vacuum to obtain 2.3 g of the resulting product 6,7-dihydroxy-4-anilinoquinazoline(100%).10099] ‘H NMR (400 MHz, DMSO) ? 9.87 (bt, 1H), 8.52 (s, 1H), 8.00 (s, 1H), 7.85 (s, 1H), 7.41-7.19 (m, 4H), 4.27 (s, 1 H)10100] ESI mlz 278.0 (M+H)
References:
US2016/175453,2016,A1 Location in patent:Paragraph 0097; 0098; 0099; 00100
938185-05-8
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13794-72-4
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$8.00/1g
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16064-15-6
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$87.00/100mg
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938185-04-7
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$102.00/100mg
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