Ethyl 3,4-dihydroxybenzoate synthesis
- Product Name:Ethyl 3,4-dihydroxybenzoate
- CAS Number:3943-89-3
- Molecular formula:C9H10O4
- Molecular Weight:182.17
Ethyl 3,4-dihydroxybenzoate can be used as food additives and pharmaceutical intermediates. It can be synthesized by esterification of 3,4-dihydroxybenzoic acid and absolute ethanol.
Yield:3943-89-3 95%
Reaction Conditions:
at 0; for 0.5 h;
Steps:
Ethyl ethers of 2,4- and 3,4-dihydroxybenzoic acids (c).
General procedure: The flask containing precursor b synthesized in the previous step was cooled in an ice bath. Then, 15mL of ethanol was added gradually while maintaining the temperature at 0 °C. The reaction mixture was stirred for 30 min, and then the excess ethanol was evaporated. The precipitated residue in the flask was washed with a small quantity of cool water and dried. The crude product was then recrystallized from ethanol. Yield 95%.
References:
Gamov;Kiselev;Murekhina;Zavalishin;Aleksandriiskii;Kosterin, D.Yu. [Journal of Molecular Liquids,2021,vol. 341,art. no. 116911]
617-05-0
208 suppliers
$40.00/20mg
3943-89-3
432 suppliers
$6.00/5g
![Benzoic acid, 4-[[bis(1,1-dimethylethyl)hydroxysilyl]oxy]-, ethyl ester](/CAS/20210305/GIF/1344113-41-2.gif)
1344113-41-2
0 suppliers
inquiry
3943-89-3
432 suppliers
$6.00/5g
![ethyl 3,4-dihydro-2H-benzo[b]1,4-dioxepine-7-carboxylate](/CAS/20210111/GIF/20986-39-4.gif)
20986-39-4
3 suppliers
inquiry
3943-89-3
432 suppliers
$6.00/5g